News

OXFORD, UK – 19 May 2015 – PsiOxus Therapeutics Ltd. (PsiOxus), the oncolytic immuno-oncology company, has closed a Series C financing round of £25 million (c$38.5 million) to progress its lead clinical candidate, enadenotucirev, and a pipeline of follow-on oncolytic programmes from the antibody ‘armed’ series of AbEnAd viruses. Woodford Investment Management joins as a new investor Founding investor Imperial Innovations led the Series C round alongside other current investors Invesco, SROne (investment arm of GlaxoSmithKline), Lundbeckfond Ventures and Mercia Technologies. In addition, one new investor, Woodford Investment Management, has joined the syndicate via the recently formed Woodford Patient Capital Trust. PsiOxus’ Chief Financial Officer, Theodora Harold, will formally present on the financing and future plans on Tuesday 19th May at the BioEquity Conference taking place in Vienna, Austria. Leapfrogging into a large market segment PsiOxus’ lead product, enadenotucirev, is an oncolytic virus that has been shown in phase I clinical trials to reach and selectively infect cancer cells when administered by intravenous infusion. The ability to deliver enadenotucirev systemically via intravenous infusion represents a significant advantage over the other oncolytic therapies currently in development that require intratumoural delivery. Furthermore, these enadenotucirev phase I clinical trials have shown that the selective infection of tumour cells by enadenotucirev leads to the infiltration of immune cells (T-cells) into colorectal tumours. PsiOxus will now use the new funding to conduct a phase I clinical study combining enadenotucirev and an immune-checkpoint inhibitor in patients with metastatic colorectal cancer. With this study, PsiOxus aims to demonstrate that the immune process triggered by enadenotucirev infection of tumour cells, will enable the activity of checkpoint inhibitors in this otherwise immune modulator resistant indication. Dr John Beadle, CEO of PsiOxus commented: “This new investment allows us to make exciting additions to our ongoing programmes. In addition to moving our enadenotucirev programme forward in a variety of solid cancer monotherapy indications, we will now be able to examine the combination of enadenotucirev with a checkpoint inhibitor in patients with metastatic colorectal cancer. This leapfrog strategy could create a substantial new commercial opportunity by introducing this exciting class of immunotherapeutic agents to the large colorectal cancer market.” Forcing cancercells to producecheckpoint inhibitors Lookingto the future, the AbEnAd platform will be used to ‘arm’ the enadenotucirev virus with the genetic instructions required to force cancer cells into producing therapeutic antibodies, opening up an exciting form of anti-cancer gene therapy whereby the metastatic tumour is forcedinto acting as an anti-cancer “drug factory.” To date PsiOxus has developed AbEnAd viruses capable of producing a wide range of functioning therapeutic antibodies including anti-PDL1 and anti-CTLA4antibodies, in preclinical studies. However, besides antibodies of different specificities, the arming platform can also be used to deliver a broad variety of biological agents including proteins, peptides, and RNAi. Up to three different therapeutic molecules can be incorporated in each virus product in order to produce combination therapies in a singledose form. PsiOxuswill now use some of the Series C funding to progress a preferred, and as yet undisclosed, internal candidate whilst continuing to seek partnerships for other applications. About PsiOxus Therapeutics, Ltd. PsiOxus Therapeutics is an Oxford, UK-based development stage biotechnology company with a particular focus in immune therapeutics in oncology. PsiOxus has developed a patented platform for tumour-targeted delivery based on its oncolytic vaccine, enadenotucirev. Enadenotucirev’s unique design allows it to be delivered systemically via intravenous administration. The anti-cancer scope of enadenotucirev can be expanded through “arming” – a process that involves addition of new genes into enadenotucirev. The "Armed EnAd" platform makes possible creation of a broad range of unique oncolytic immune therapeutics, including oncolytic vaccines that express one or more antibodies (AbEnAd), cytokines or other immunomodulatory proteins, or nucleotide based payloads such as RNAi. The Armed EnAd platform is in preclinical stage, while phase I/II clinical trials are ongoing with the parent unarmed EnAd in different tumour types. About Woodford Investment Management Woodford Investment Management is a fast-growing asset management company built on a founding philosophy of transparency and simplicity. Launched in May 2014, the company has more than £11bn assets under management and advice. Contacts: Media Enquiries:

Mike Beyer

Sam Brown Inc. Health Communications

312-961-2502

mikebeyer@sambrown.com